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Cyclodextrin (CD) is a kind of cyclic oligosaccharide compound formed by the D-glucopyrane unit by the α-1 4-glycoside bond. At present, the most studied molecules containing 6, 7 and 8 glucose units are α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin, respectively.Of alpha and gamma cyclodextrin solubility in water is big, not easy to get crystallization, and the cost is high, the production of unsafe, potentially toxic, and B - CD's superiority in this respect, as a result of B - CD in the human body is not easy to decompose in the stomach and digestive enzymes and the role of the gut microbes in the gut first broken ring opening form oligosaccharides, and as a normal metabolism of carbohydrate in the body, have no cumulative effect, and is an ideal carrier, and acute and chronic toxicity experiment, teratogenic carcinogenic and mutagenic experiment proves that this product use safe non-toxic, so beta cyclodextrins in three kinds of cyclodextrin is the most widely used, the most easily into and cheap.The applications of cyclodextrin are mainly in the fields of medicine, chemical industry and materials. 

Preparation method of B-CD

1. 1. 1 saturated aqueous solution method: according to the different adding state of drugs, it can be divided into liquid-liquid method and liquid-solid method.The drug or other solution is added to the saturated B-CD aqueous solution, stirred at a specified temperature for a certain time, then cooled to crystallize, filtered and dried.This is the most commonly used method in the current research, which is generally carried out in magnetic stirrer or electric stirrer.

1. 1.2 Ultrasonic method: Add the drug into B-CD saturated aqueous solution with ultrasonic crushing instrument or ultrasonic cleaning machine, select the appropriate ultrasonic intensity and time, and dispose the precipitated precipitate as above method.This method is simple and quick.The volatile oil inclusion complex was prepared by ultrasonic method, which was easy to operate and had high inclusion rate. Compared with the saturated water solution method, the yield was 17.88% and the inclusion rate was 11.51% higher.The garlic oil inclusion compound obtained by this method can improve the yield and reduce the odor, which is considered superior to the electric stirring method.

1. 1. 3 Grinding method: mixing B-CD with a certain amount of solid drugs, grinding it in a ball mill or emulsion for a certain time to get the finished product.In the experiment, the heme b-cd inclusion compound was prepared by grinding method, which increased the solubility and dissolution, improved the bioavailability of heme, concealed the fishy smell of heme, and opened up a good prospect for its processing into various dosage forms.However, this method is only carried out in a small amount, and manual operation is not suitable for large-scale production.The colloid mill method instead of grinding method is fast, simple and suitable for industrial production.