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Hydroxypropyl betadex is widely used in the industry, but many people don't know its inclusion effect in cefoperadine. Cefradine is an important class of anti infective drugs, which is used to treat systemic infections caused by allergic micro organic substances. However, the solubility of cefradine in water was only 16.8 mg, which affected its curative effect and limited its application. Therefore, it is necessary and valuable to prepare corresponding inclusion complexes to increase their water solubility and stability.

Hydroxypropyl β-cyclodextrin is a kind of pharmaceutical excipient with broad prospects. It is not only soluble in aqueous solution, but also soluble in alcohol aqueous solution. It is heat stable, non-toxic to kidney and almost no stimulation to muscle and mucous membrane. A large number of experiments have confirmed that the solubility and stability of a variety of insoluble drugs have been improved in varying degrees after inclusion with hydroxypropyl betadex. In the experiment, hydroxypropyl - β - cyclodextrin was used to study the solubilization effect and stability of cefradine. The results showed that hydroxypropyl - β - cyclodextrin increased the solubility of cefradine in water by 5.3 times, and the stability was also improved obviously.

About the inclusion of hydroxypropyl β - cyclodextrin in Cefradine, you can refer to it. Later, if you want to know more about cyclodextrin, you can continue to pay attention to us.