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Dined Uses Hydroxypropyl Betadex Better
Time：2020/11/28
Class：NEWS
Dined is easily decomposed, especially in aqueous solution and light conditions. The content of the main preparation containing Dineide drops rapidly during the shelf life, which affects the stability of the product. Therefore, solving the problem of easy decomposition by changing the physical and chemical properties of dined is the key technology to ensure the stability of dined.

Using cyclodextrin as the host molecule and nedide as the guest molecule, the molecular inclusion technology is used to encapsulate the nedide molecule in the cavity of the cyclodextrin molecule to form a molecular inclusion compound, and the inclusion compound is made External preparation. The molecular ratio of dinide to cyclodextrin in the inclusion compound is 1: 1, preferably 1: 5. The cyclodextrin includes cyclodextrin and its derivatives, and it is recommended to use hydroxypropyl-β-cyclodextrin.

The ethanol solution of dined was added to the aqueous solution of cyclodextrin for inclusion. Compared with the unencapsulated dined, the stability of the cyclodextrin inclusion compound and the preparation prepared with the inclusion compound was significantly improved.


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