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Carboxymethyl-β-cyclodextrin (CM-β-CD) as a cyclodextrin derivatives, mainly through cyclodextrins in alkaline environment with chloroacetic acid reaction, the reaction conditions are mild, The reaction process is simple and the yield is high. And CM-β-CD contains carboxyl anions, has a high solubility and envelope effect, as early as the 20th century, 80 years was applied to the chromatographic separation. In recent years, in view of the excellent performance of CM-β-CD, CM-β-CD is widely used in adsorbents, molecular self-assembly, chromatographic additives and drug carriers and so on. In addition, CM-β-CD can be further through the polymerization and grafting of other polymers, inorganic or organic materials to generate new functional materials, scientists become one of the hot spots.

CM-β-CD is a compound formed by linking a carboxymethyl group with a cyclodextrin cavity through an ether bond, which has the following characteristics: (1) linking the carboxymethyl group to the edge of the cyclodextrin cavity via an ether bond, The hydrogen atoms in the carboxyl group can form hydrogen bonds with the hydrogen in the water molecules, which greatly improves the water solubility of the cyclodextrin. (2) The edge of the cyclodextrin cavity Of the carboxyl group is anionic groups, in a weak acid or alkaline environment can be dissociated into - COO ~, with metal ions to form complexes, and other molecules to improve the interaction between the molecules. According to the above characteristics, the CM-β-CD molecule with better water solubility can not only form the inclusion complex with other compounds, but also the carboxyl group contained in the molecule can enhance the hydrogen bond, static electricity, dipole and so on with other molecules Interaction, and thus in medicine, separation and analysis, biological sciences, environmental protection, sewage treatment and other aspects have a very good application.