NEWS

Cyclodextrins are cyclic oligosaccharides formed by d-glucose units linked by α-1, 4 bonds. They have a hydrophobic central cavity and a hydrophilic outer surface, which can encapsulate various inorganic/organic molecules and form host/guest inclusion complexes, often used as solvent-increasing and permeating agents. Inclusion of drug molecules improves the physicochemical properties of drugs, such as solubility, dissolution rate, stability and bioavailability, showing great potential for formulation development. Natural cyclodextrins are usually divided into α, β and γ-CD. Cyclodextrins and their derivatives, as intermediates of pharmaceutical preparations, are mainly used to increase solubility, improve stability, solid liquid drugs, reduce irritation and improve bioavailability, etc., which is a hot new preparation technology.

In terms of the use of antibiotics, the preparation of many antibiotics into a new formulation of cyclodextrin inclusion complex can not only improve the solubility of antibiotics, but also facilitate the promotion of the application of antibiotics reduction, which can significantly slow down the generation of drug resistance. In conclusion, the successful preparation of new dosage forms of inclusion complexes improves the dissolution efficiency and permeability of guest drugs, which has important guiding significance for the improvement of insoluble drugs and the development of new preparations.