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Cinnamaldehyde is not soluble in water, volatile and easy to oxidation. By spray drying method, hydroxypropyl-cyclodextrin (HP-β -CD) is prepared as wall material, and the structure, thermal stability and slow release characteristics of the inclusion are studied.The results showed that when the mass ratio of cinnamaldehyde and hydroxypropyl-cyclodextrin was 1:2, the feed speed was 20 mL/min and the inlet temperature was 180℃, confirming the formation of cinnamaldehyde inclusion was significantly improved and the thermal stability of cinnamaldehyde after embedding.Over time, the bacterial body inhibition rate under the protection of the wall material has decreased slowly, and it has a lasting and stable antibacterial effect.Therefore, the inclusion compound has a slow-release antibacterial effect and better water solubility.

The introduction of hydroxypropyl breaks the intramolecular cyclic hydrogen bond of bettacyclodextrin, overcoming the major drawback of poor water solubility while maintaining the cyclodextrin cavity.It is one of the most intensively studied and widely used cyclodextrin derivatives.Mainly used in the food, medicine, cosmetics industry.1. In the pharmaceutical industry: because the relative surface activity and hemolysis activity are relatively low and not irritating to muscles, so hydroxypropylbecide cyclodextrin is an ideal injection solvent and drug excipients.It can improve the water solubility of insoluble drugs, increase the stability of drugs, improve the bioavailability of drugs, increase the efficacy of drugs or reduce the dosage, can adjust or control the release speed of drugs, and reduce the toxic and side effects of drugs.It can be used for oral drugs, injections, mucosal delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal absorption delivery system, lipophilic targeted drugs, and can also be used as a protein protective agent and stabilizer.2. In the field of food and spices: Hydroxypropyl times cyclodextrin can improve the stability and long-term effect of nutritional molecules, cover up or correct the bad smell and taste of food nutritional molecules, and improve the production process and product quality.The product is very soluble in water, the substitution degree 4 or above can be miscible with water in any proportion, and also dissolved in 50% ethanol and methanol.3. In the field of cosmetic raw materials: hydroxypropyl times cyclodextrin is used as a stabilizer, emulsifier, flavor-removing agent, etc., which can reduce the stimulation of organic molecules in cosmetics on the skin and mucosal tissue, enhance the stability of active ingredients, and prevent the volatilization and oxidation of nutrients.