NEWS

The cyclodextrin and its derivatives form part of the inclusion complex with the guest for protection, sustained release or solubilization, in which case the guest molecule is ultimately released from the cyclodextrin. Studies have shown that the main factors that cause or accelerate the release of guest molecules are concentration changes and competitive substitutions, with less effect on temperature and pH. When the concentration of the solution changes greatly, the guest will be released in a short time. For example, the cyclodextrin compound drug will be released quickly after being injected into the body, and has almost no effect on the original pharmacology of the drug. However, for the inclusion complex with greater binding force, the influence of concentration gradually decreases or even has no effect, and competitive substitution becomes the main factor. Small molecules such as methanol and ethanol can competitively replace the guest of the inclusion complex. The binding constant is determined by the nature of the cyclodextrin and the guest molecule, and the hydroxypropyl beta cyclodextrin has a higher binding constant than the parent cyclodextrin.