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β-Cyclodextrin (β-CD) and its derivatives have become the subject of extensive research by researchers in the fields of drug modification, molecular recognition, chiral separation, and environmental protection due to their unique structure and properties. β-Cyclodextrin looks like a "cone" with a hydrophobic cavity and a hydrophilic surface. It can selectively form host-guest or supramolecular complexes with various organic, inorganic, and biological molecules, so it is often used as a molecule The main body to study its molecular recognition of various organic, inorganic, and biological molecules. As a host model, cyclodextrin is compounded with guest molecules, which can increase the solubility of the guest. However, because the solubility of cyclodextrin itself is small, its cavity size is also fixed, so it is used as a molecular recognition agent and solubilizer. There are big limitations.

In recent years, in order to meet the needs of the national economy and people's lives, various cyclodextrin derivatives have been synthesized. There are a large number of primary and secondary hydroxyl groups on cyclodextrin, and these hydroxyl groups (especially the 2, 3 and 6 hydroxyl groups) are different. The physicochemical properties of the compound are used as a modification point, and many cyclodextrin derivatives with new functional groups have been synthesized. The main reaction types are: alkylation, hydroxylation, branching and so on. The introduction of these groups generally does not affect the capacity of the central cavity to accommodate guest molecules, but improves certain physical and chemical properties and inclusion capabilities of CD. At present, the main applications of cyclodextrin derivatives are divided into three categories: hydrophilic, hydrophobic and ionic. Hydrophilic derivatization mainly includes methyl cyclodextrin, hydroxyethyl cyclodextrin, hydroxypropyl cyclodextrin, etc., which have greater water solubility in water. Among them, the most studied derivatives are β-cyclodextrin, especially water-soluble β-cyclodextrin derivatives such as methyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin, and sulfobutyl-β-cyclodextrin and so on.

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. has produced cyclodextrins for more than ten years, and the number of products has reached more than forty kinds. Feel free to connect us.