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Insoluble drugs refer to drugs with poor water solubility, which will lead to difficulty in absorption and transportation of drugs in vivo and low bioavailability. About 40% of the newly discovered natural active substances and nearly 60% of the chemically synthesized drugs are insoluble drugs, and their solubility (in water) is poor, so it is difficult to achieve satisfactory clinical efficacy, so it has not been further successfully developed into new drugs. Therefore, using physical and chemical means to improve the solubility of insoluble drugs, so as to improve their clinical efficacy, is one of the important directions of new drug research and development. Betadex Sulfobutyl Ether Sodium is a derivative of β-cyclodextrin. Because of its good water solubility and biocompatibility, sodium sulfobutyl-β-cyclodextrin can significantly increase the solubility and bioavailability of drugs. Meanwhile, it has the biological activity and low nephrotoxicity similar to heparin. As a new injection drug carrier, it has become one of the hot spots in the research and development of new drugs at home and abroad.

The new injection delivery carrier Betadex Sulfobutyl Ether Sodium and insoluble drugs such as docetaxel, amiodarone and cyanobacetin were used as the research objects to study the preparation of the inclusion complex with sulfobutyl -β-cyclodextrin sodium for injection. It has laid a theoretical foundation for the application of Betadex Sulfobutyl Ether Sodium in the development of new drugs and clinical application.

In the fight against the new crown epidemic situation, the new drug redcivir was confirmed to be effective. Betadex Sulfobutyl Ether Sodium was the necessary cosolvent for the preparation of Remdesivir.

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. has cooperated with Shandong University to set up a research and development laboratory, which is committed to the research of beta cyclodextrin and its derivatives, sulfobutyl beta cyclodextrin and hydroxypropyl beta cyclodextrin, and provide technical support for the majority of customers on the inclusion complex of beta cyclodextrin and its derivatives. Welcome to discuss cooperation!